In May 2021, it was announced that Pedretti will star in the upcoming film Lucky, based on the memoir of the same name. A clip from the film featuring Pedretti served as the music video for Musgraves' song "Simple Times". In 2021, Pedretti appeared in singer-songwriter Kacey Musgraves' film Star-Crossed, a companion feature to Musgraves' album of the same name, in a cameo role as a woman participating in a heist.
Screen Rant wrote in 2021 that "if there is any performance that has absolutely been a star-making one, one would need look no further than Victoria Pedretti's incredible work." For her performance, she earned a nomination from the Critics' Choice Super Awards and won the award for Best Frightened Performance at the 2021 MTV Movie & TV Awards.
Pedretti was next announced to lead the follow-up season to Hill House, later revealed to be titled The Haunting of Bly Manor, which was released in 2021 to positive reception.
In 2020, Pedretti guest-starred in the anthology series Amazing Stories as Evelyn Porter, and in the same year starred as Katherine in the biographical-drama film Shirley, the latter of which received positive reviews from critics. In 2019, Pedretti appeared as Leslie Van Houten in Quentin Tarantino's comedy-drama film Once Upon a Time in Hollywood, which was a commercial success, and earned her a nomination for the Critics' Choice Movie Award for Best Acting Ensemble. We played a couple before, but it didn't just immediately come back after being in a global pandemic."
It'll be fine.' So it took months to figure out how to do it safely. Filming was done amidst the COVID-19 pandemic, where the intimate scenes posed a challenge for the actress to film, stating that "This is not a show where you can be like, 'Nobody's going to kiss. She reprised the role for the third season of You, which was released on October 15, 2021. The second season was released by Netflix on December 26, 2019, with Pedretti's performance and the show being received positively. Pedretti auditioned for the role of Guinevere Beck on the thriller series You although she was initially rejected, the directors later cast her as Love Quinn in the show's second season after seeing her previous acting work and her chemistry with her co-star Penn Badgley. Pedretti stated that the role of Dani helped her to grow comfortable towards playing darker roles in the horror and thriller genres, later stating that she has "got a knack for" them. She was lauded for her performance, and earned Saturn Award and MTV Award nominations in 2019 she was promptly established as a modern-day scream queen.
Pedretti rose to prominence for her role on Netflix's 2018 series The Haunting of Hill House, where she played Eleanor "Nell" Crain Vance. Maybe you should try directing.’ And I was like, that's not easier." Career She stated: "They were like, ‘I don’t know if you’re cut out for this. In an interview with Collider, Pedretti said that she was told by her faculty not to pursue acting. Pedretti attended Pennsbury High School in Fairless Hills where she expressed an interest in musical theatre, and the Carnegie Mellon School of Drama in Pittsburgh, where she earned a Bachelor of Fine Arts in acting in 2017. Regarding her parents, she stated that she "loves them very much, and they tried their best." She was diagnosed with ADD when she was six years old.
In a 2021 interview, she revealed that she grew up in an emotionally abusive household. Her father Mike Pedretti is of three-quarter Italian descent, and her maternal grandmother was Ashkenazi Jewish.